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» Bioanalytical Services » Bioanalysis Small Molecules  


Bioanalysis Small Molecules

LC-MS analyses for your pharmacokinetic and toxicokinetic preclinical studies as well as for your clinical trials are performed in a GLP compliant environment.

We perform all modern sample preparation methods, like solid-phase extraction, liquid-liquid extraction and on-line column switching techniques. The large degree of automation ensures high reproducibility of the entire workflow.

Swiss BioAnalytics offers LC-MS/MS method development, method validation and quantitation of your analytes in biological matrices like plasma, serum, tissue, and urine.

We have in-depth knowledge of inlet- and sample preparation techniques and are your ideal outsourcing partner for all bioanalytical challenges of your drug development pipeline.

  • Experiments in Early Stage of Drug Discovery
  • Preclinical Studies
  • Clinical Studies

 

Please see here some recent publications that we have published together with clients:

Validation of an LC-MS/MS method for the quantitative determination of the orexin receptor antagonist almorexant and its four primary metabolites in human plasma. www.ncbi.nlm.nih.gov/pubmed/24531213

Validated LC-MS/MS method for the quantitative determination of the glucosylceramide synthase inhibitor miglustat in mouse plasma and human plasma and its application to a pharmacokinetic study. www.ncbi.nlm.nih.gov/pubmed/22079117

Simultaneous determination of capecitabine and its metabolite 5-fluorouracil by column switching and liquid chromatographic/tandem mass spectrometry. www.ncbi.nlm.nih.gov/pubmed/15329840